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Contraindications
Hypersensitivity to polymyxins; perforated ear drums (otic). Concurrent use w/ nephrotoxic and/or neurotoxic drugs and neuromuscular blockers.
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Special Precautions
Patients w/ pre-existing nitrogen retention. Renal impairment. Pregnancy and lactation. Patient Counselling Eye drop/oint may cause temporary blurred vision or other visual disturbances which may affect ability to drive or operate machinery. Monitoring Parameters Monitor renal function; neurologic symptoms; signs of superinfection.
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Adverse Reactions
Facial flushing, fever, rash, pruritus, urticaria, skin exanthema, eosinophilia, dizziness, ataxia; severe pain at inj sites (IM), thrombophlebitis (IV) at inj sites. Ophth: ocular discomfort, keratitis, eye irritation.
Potentially Fatal: Nephrotoxicity, neurotoxicity (higher doses or in patients w/ renal impairment); resp paralysis, anaphylaxis, Clostridium difficile-associated diarrhoea and pseudomembranous colitis. |
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ROUTE(S) : Otic / Topical: C
FDA pregnancy category C applies to polymyxin B in combination w/ other drugs.
ROUTE(S) : Ophth: C
FDA pregnancy category C applies to polymyxin B in combination with other drugs.
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ATC Classification
A07AA05 - polymyxin B ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
S03AA03 - polymyxin B ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. S02AA11 - polymyxin B ; Belongs to the class of antiinfectives used in the treatment of ear infections. S01AA18 - polymyxin B ; Belongs to the class of antibiotics. Used in the treatment of eye infections. J01XB02 - polymyxin B ; Belongs to the class of polymyxins. Used in the systemic treatment of infections. |
